Large Tumor Suppressor Kinase 1 (LATS1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Large Tumor Suppressor Kinase 1 (LATS1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1. |
| Other Names | LATS, large tumor suppressor, homolog 1 (Drosophila), LATS1, WARTS, wts, H-warts, Large tumor suppressor 1, WARTS protein kinase, Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, LATS, LATS, LATS , LATS , large tumor suppressor, large tumor suppressor, large tumor suppressor , large tumor suppressor , homolog 1 (Drosophila), homolog 1 (Drosophila), homolog 1 (Drosophila) , homolog 1 (Drosophila) , LATS1, LATS1, LATS1 , LATS1 , WARTS, WARTS, WARTS , WARTS , wts, wts, wts , wts , H-warts, H-warts, H-warts , H-warts , Large tumor suppressor 1, Large tumor suppressor 1, Large tumor suppressor 1 , Large tumor suppressor 1 , WARTS protein kinase, WARTS protein kinase, WARTS protein kinase , WARTS protein kinase , Serine/threonine-protein kinase LATS1, Serine/threonine-protein kinase LATS1, Serine/threonine-protein kinase LATS1 , Serine/threonine-protein kinase LATS1 , Large tumor suppressor homolog 1, Large tumor suppressor homolog 1, Large tumor suppressor |
| Gene, Accession # | NCBI: NP_001257448.1, NP_004681.1, UniProt: O95835 |
| Catalog # | abx033135 |
| Price | please inquire |
| Order / More Info | Large Tumor Suppressor Kinase 1 (LATS1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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