Tumor Suppressor ARF (CDKN2A) Antibody from ABBEXA LTD
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| Antigenic Specificity | Tumor Suppressor ARF (CDKN2A) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. |
| Immunogen | KLH-conjugated synthetic peptide between 39-65 amino acids from the Central region of mouse Cdkn2a. |
| Other Names | CDKN2A, Cyclin Dependent Kinase Inhibitor 2A, P14ARF, CDK4I, MTS1, ARF, CDKN2, CMM2, INK4, P16, P19, P14, MLM, Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4), Cyclin-Dependent Kinase 4 Inhibitor A, Cyclin-Dependent Kinase Inhibitor 2A, Multiple Tumor Suppressor 1, p14 ARF, Alternative Reading Frame, Alternative Reading Frame p14, P16-INK4A, P16INK4A, P19Arf, INK4a, MTS-1, Cell Cycle Negative Regulator Beta, CDK4 Inhibitor P16-INK4, Tumor Suppressor ARF, P16-INK4a, P16-INK4, P16INK4, P19ARF, INK4A, TP16, cyclin-dependent kinase inhibitor p12, cyclin-dependent kinase inhibitor p16, CDKN2A, CDKN2A, CDKN2A , CDKN2A , Cyclin Dependent Kinase Inhibitor 2A, Cyclin Dependent Kinase Inhibitor 2A, Cyclin Dependent Kinase Inhibitor 2A , Cyclin Dependent Kinase Inhibitor 2A , P14ARF, P14ARF, P14ARF , P14ARF , CDK4I, CDK4I, CDK4I , CDK4I , MTS1, MTS1, MTS1 , MTS1 , ARF, ARF, ARF , ARF , CDKN2, CDKN2, CDKN2 , CDKN2 , CMM2, CMM2, CMM2 , CMM2 , INK4, INK4, INK4 , INK4 , P |
| Gene, Accession # | CDKN2A, Gene ID: 12578, UniProt: Q64364 |
| Catalog # | abx030864 |
| Price | please inquire |
| Order / More Info | Tumor Suppressor ARF (CDKN2A) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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