Zinc Finger Protein Gfi-1b (GFI1B) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Zinc Finger Protein Gfi-1b (GFI1B) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Zinc Finger Protein Gfi-1b (GFI1B) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. |
| Immunogen | KLH-conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B. |
| Other Names | GFI 1B, gfi1b, GFI1B protein, Growth factor independent 1B protein, Growth factor independent 1B transcription repressor, Growth factor independent protein 1B, OTTHUMP00000022443, OTTHUMP00000022444, OTTHUMP000000235527, Potential regulator of CDKN1A, Potential regulator of CDKN1A translocated in CML, Translocated in CML, Zinc finger protein Gfi-1b, Zinc finger protein, Gfi-1bGrowth factor independent protein 1B, GFI 1B, GFI 1B, GFI 1B , GFI 1B , gfi1b, gfi1b, gfi1b , gfi1b , GFI1B protein, GFI1B protein, GFI1B protein , GFI1B protein , Growth factor independent 1B protein, Growth factor independent 1B protein, Growth factor independent 1B protein , Growth factor independent 1B protein , Growth factor independent 1B transcription repressor, Growth factor independent 1B transcription repressor, Growth factor independent 1B transcription repressor , Growth factor independent 1B transcription repressor , Growth factor independent protein 1B, Growth factor independent protein 1B, Gro |
| Gene, Accession # | NCBI: NP_001128503.1, NP_004179.3, UniProt: Q5VTD9 |
| Catalog # | abx034803 |
| Price | please inquire |
| Order / More Info | Zinc Finger Protein Gfi-1b (GFI1B) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies