Protein SET (SET) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Protein SET (SET) antibody, protein, ELISA kits.
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| Antigenic Specificity | Protein SET (SET) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL) induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. |
| Immunogen | KLH-conjugated synthetic peptide between 47-75 amino acids from the N-terminal region of human SET. |
| Other Names | 2PP2A, IGAAD, TAF-I, I2PP2A, IPP2A2, PHAPII, TAF-IBETA, Protein SET, HLA-DR-associated protein II, Inhibitor of granzyme A-activated DNase, Phosphatase 2A inhibitor I2PP2A, I-2PP2A, Template-activating factor I, SET, SET nuclear oncogene, LA-DR-associated protein II, OTTHUMP00000022286, SET translocation (myeloid leukemia-associated), Template-Activating Factor-I, chromatin remodelling factor, inhibitor of g, 2PP2A, 2PP2A, 2PP2A , 2PP2A , IGAAD, IGAAD, IGAAD , IGAAD , TAF-I, TAF-I, TAF-I , TAF-I , I2PP2A, I2PP2A, I2PP2A , I2PP2A , IPP2A2, IPP2A2, IPP2A2 , IPP2A2 , PHAPII, PHAPII, PHAPII , PHAPII , TAF-IBETA, TAF-IBETA, TAF-IBETA , TAF-IBETA , Protein SET, Protein SET, Protein SET , Protein SET , HLA-DR-associated protein II, HLA-DR-associated protein II, HLA-DR-associated protein II , HLA-DR-associated protein II , Inhibitor of granzyme A-activated DNase, Inhibitor of granzyme A-activated DNase, Inhibitor of granzyme A-activated DNase , Inhibitor of granzyme A-activated DNase |
| Gene, Accession # | UniProt: Q01105 |
| Catalog # | abx028158 |
| Price | please inquire |
| Order / More Info | Protein SET (SET) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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