Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody from ABBEXA LTD
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| Antigenic Specificity | Guanylyl Cyclase-Activating Protein 1 (GUCA1A) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Guanylate cyclase-activating protein is a l Ca (2+) binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca (2+) binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality. |
| Immunogen | KLH-conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1. |
| Other Names | GCAP1, GUCA1A, C6orf131, GCAP, GUCA1, Guanylyl cyclase-activating protein 1, Guanylate cyclase activator 1A, GCAP1, GCAP1, GCAP1 , GCAP1 , GUCA1A, GUCA1A, GUCA1A , GUCA1A , C6orf131, C6orf131, C6orf131 , C6orf131 , GCAP, GCAP, GCAP , GCAP , GUCA1, GUCA1, GUCA1 , GUCA1 , Guanylyl cyclase-activating protein 1, Guanylyl cyclase-activating protein 1, Guanylyl cyclase-activating protein 1 , Guanylyl cyclase-activating protein 1 , Guanylate cyclase activator 1A, Guanylate cyclase activator 1A, Guanylate cyclase activator 1A , Guanylate cyclase activator 1A |
| Gene, Accession # | UniProt: P43080 |
| Catalog # | abx028514 |
| Price | please inquire |
| Order / More Info | Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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