Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Lymphoid Enhancer Binding Factor 1 (LEF1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Lymphoid Enhancer Binding Factor 1 (LEF1) antibody is a Rabbit polyclonal antibody for the detection of LEF1. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
| Immunogen | lymphoid enhancer-binding factor 1 |
| Other Names | LEF-1, TCF10, TCF7L3, TCF1 Alpha, Lymphoid enhancer-binding factor 1, LEF1, T cell-specific transcription factor 1-alpha, LEF-1, LEF-1, LEF-1 , LEF-1 , TCF10, TCF10, TCF10 , TCF10 , TCF7L3, TCF7L3, TCF7L3 , TCF7L3 , TCF1 Alpha, TCF1 Alpha, TCF1 Alpha , TCF1 Alpha , Lymphoid enhancer-binding factor 1, Lymphoid enhancer-binding factor 1, Lymphoid enhancer-binding factor 1 , Lymphoid enhancer-binding factor 1 , LEF1, LEF1, LEF1 , LEF1 , T cell-specific transcription factor 1-alpha, T cell-specific transcription factor 1-alpha, T cell-specific transcription factor 1-alpha , T cell-specific transcription factor 1-alpha |
| Gene, Accession # | LEF1, Gene ID: 51176, UniProt: Q9UJU2 |
| Catalog # | abx216546 |
| Price | please inquire |
| Order / More Info | Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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