Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) antibody, protein, ELISA kits.
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| Antigenic Specificity | Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. |
| Immunogen | KLH-conjugated synthetic peptide between 11-42 amino acids from the N-terminal region of human ARH (LDLRAP1). |
| Other Names | ARH, LDL receptor adaptor protein, ARH2, FHCB1, FHCB2, MGC34705, DKFZp586D0624, low density lipoprotein receptor adaptor protein 1, RP11-70P17.2, autosomal recessive hypercholesterolemia protein, LDLRAP1, Low density lipoprotein receptor adapter protein 1, ARH, ARH, ARH , ARH , LDL receptor adaptor protein, LDL receptor adaptor protein, LDL receptor adaptor protein , LDL receptor adaptor protein , ARH2, ARH2, ARH2 , ARH2 , FHCB1, FHCB1, FHCB1 , FHCB1 , FHCB2, FHCB2, FHCB2 , FHCB2 , MGC34705, MGC34705, MGC34705 , MGC34705 , DKFZp586D0624, DKFZp586D0624, DKFZp586D0624 , DKFZp586D0624 , low density lipoprotein receptor adaptor protein 1, low density lipoprotein receptor adaptor protein 1, low density lipoprotein receptor adaptor protein 1 , low density lipoprotein receptor adaptor protein 1 , RP11-70P17.2, RP11-70P17.2, RP11-70P17.2 , RP11-70P17.2 , autosomal recessive hypercholesterolemia protein, autosomal recessive hypercholesterolemia protein, autosomal recessive hypercholes |
| Gene, Accession # | UniProt: Q5SW96 |
| Catalog # | abx033818 |
| Price | please inquire |
| Order / More Info | Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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