Dnmt1 (pS714) Antibody from ABBEXA LTD
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| Antigenic Specificity | Dnmt1 (pS714) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, DB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells. |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S714 of human Dnmt1. |
| Other Names | Acetyl-DNMT1-K1127/K1129/K1131/K1133, DNMT1, AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, DNA methyltransferase HsaI, DNA MTase HsaI, M.HsaI, DNA (cytosine-5) methyltransferase 1, DNA (cytosine-5-)-methyltransferase 1, FLJ16293, MGC104992, DNA methyltransferase 1, Acetyl-DNMT1-K1127/K1129/K1131/K1133, Acetyl-DNMT1-K1127/K1129/K1131/K1133, Acetyl-DNMT1-K1127/K1129/K1131/K1133 , Acetyl-DNMT1-K1127/K1129/K1131/K1133 , DNMT1, DNMT1, DNMT1 , DNMT1 , AIM, AIM, AIM , AIM , DNMT, DNMT, DNMT , DNMT , MCMT, MCMT, MCMT , MCMT , CXXC9, CXXC9, CXXC9 , CXXC9 , HSN1E, HSN1E, HSN1E , HSN1E , ADCADN, ADCADN, ADCADN , ADCADN , DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 1 , DNA (cytosine-5)-methyltransferase 1 , CXXC-type zinc finger protein 9, CXXC-type zinc finger protein 9, CXXC-type zinc finger protein 9 , CXXC-type zinc finger protein 9 , DNA methyltransferas |
| Gene, Accession # | UniProt: P26358 |
| Catalog # | abx032017 |
| Price | please inquire |
| Order / More Info | Dnmt1 (pS714) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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