SHARPIN (SHARPIN) Antibody from ABBEXA LTD
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| Antigenic Specificity | SHARPIN (SHARPIN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | SHARPIN (SHARPIN) antibody is a Rabbit polyclonal antibody for the detection of SHARPIN. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. |
| Immunogen | SHANK-associated RH domain interactor |
| Other Names | hSIPL1, SHARPIN, SIPL1, hSIPL1, hSIPL1, hSIPL1 , hSIPL1 , SHARPIN, SHARPIN, SHARPIN , SHARPIN , SIPL1, SIPL1, SIPL1 , SIPL1 |
| Gene, Accession # | Gene ID: 81858, UniProt: Q9H0F6 |
| Catalog # | abx240065 |
| Price | please inquire |
| Order / More Info | SHARPIN (SHARPIN) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
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