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Antigenic Specificity | Recombination Activating Gene 2 (RAG2) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This product is currently in development. The lead time for this product may be several months. Please contact us at info@abbexa.com for an updated lead time before purchasing this product. This gene encodes a protein that is involved in the initiation of V (D) J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. |
Immunogen | KLH-conjugated synthetic peptide between 349-377 amino acids from the C-terminal region of human RAG2. |
Other Names | RAG-2, RAG2, V (D) J recombination-activating protein 2, RAG-2, RAG-2, RAG-2 , RAG-2 , RAG2, RAG2, RAG2 , RAG2 , V (D) J recombination-activating protein 2, V (D) J recombination-activating protein 2, V (D) J recombination-activating protein 2 , V (D) J recombination-activating protein 2 |
Gene, Accession # | UniProt: P55895 |
Catalog # | abx026817 |
Price | please inquire |
Order / More Info | Recombination Activating Gene 2 (RAG2) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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