Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN (PTEN) Antibody from ABBEXA LTD
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| Antigenic Specificity | Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN (PTEN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PTEN antibody is a Rabbit polyclonal antibody against PTEN. This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. |
| Immunogen | Recombinant protein of human PTEN. |
| Other Names | 10q23del, BZS, DEC, MGC11227, MHAM, MMAC1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PTEN, PTEN1, TEP1, GLM2, Platelet antigen BR, PTEN 1, Tensin homolog, TEP 1, VLA 2 Receptor Alpha Subunit, PTEN (Phospho-Ser370), Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, Mitochondrial Phosphatase And Tensin Protein Alpha, Mitochondrial Phosphatase And Tensin Protein , Phosphatase And Tensin-Like Protein, Mitochondrial PTENalpha, Mitochondrial PTEN alpha, Mitochondrial PTEN, Mitochondrial PTEN , CWS1, Phosphatidylinositol 345-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, Phosphatidylinositol-345-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, 10q23del, 10q23del, 10q23del , 10q23del , BZS, BZ |
| Gene, Accession # | PTEN, Gene ID: 5728, UniProt: P60484 |
| Catalog # | abx001725 |
| Price | please inquire |
| Order / More Info | Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN (PTEN) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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