Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody from ABBEXA LTD
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| Antigenic Specificity | Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs. PI4K II is activated by detergent and inhibited by adenosine. Overexpression of PI4KII in COS-7 cells increases synthesis of PtdIns4P. Some cells overexpressing PI4KII have scattered or no perinuclear Golgi. Knockdown of PI4KII by RNA interference (RNAi) does not disrupt the Golgi, and some cells show expanded Golgi. RNAi reduces the Golgi level of PtdIns4P and blocks the association between AP1 and the trans-Golgi network. PI4KII RNAi had little effect on intra-Golgi trafficking, but it inhibited export to plasma membrane export by 35%. It has been proposed that PI4KII generates PtdIns4P-rich domains within the Golgi that specify docking of the AP1 coat machinery. |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PI4K2A (PI4K II). |
| Other Names | PI4K2A, Phosphatidylinositol 4-kinase type 2-alpha, Phosphatidylinositol 4-kinase type II-alpha, PI4KII, PIK42A, PI4K2A, PI4K2A, PI4K2A , PI4K2A , Phosphatidylinositol 4-kinase type 2-alpha, Phosphatidylinositol 4-kinase type 2-alpha, Phosphatidylinositol 4-kinase type 2-alpha , Phosphatidylinositol 4-kinase type 2-alpha , Phosphatidylinositol 4-kinase type II-alpha, Phosphatidylinositol 4-kinase type II-alpha, Phosphatidylinositol 4-kinase type II-alpha , Phosphatidylinositol 4-kinase type II-alpha , PI4KII, PI4KII, PI4KII , PI4KII , PIK42A, PIK42A, PIK42A , PIK42A |
| Gene, Accession # | UniProt: Q9BTU6 |
| Catalog # | abx033831 |
| Price | please inquire |
| Order / More Info | Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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