Edit |   |
---|---|
Antigenic Specificity | Mothers Against Decapentaplegic Homolog 1 (SMAD1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. |
Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SMAD1. |
Other Names | BSP-1, BSP1, Dwarfin-A, Dwf-A, JV4-1, MADH1, MADR1, Mad-related protein 1, Mad1, Mothers against DPP homolog 1, Mothers against decapentaplegic homolog 1, Mothers-against-DPP-related-1, SMAD 1, Transforming growth factor beta signaling protein-1, MAD homolog 1, SMAD family member 1, Smad1, hSMAD1, Transforming growth factor-beta-signaling prot, Transforming growth factor-beta-signaling protein 1, JV41, BSP-1, BSP-1, BSP-1 , BSP-1 , BSP1, BSP1, BSP1 , BSP1 , Dwarfin-A, Dwarfin-A, Dwarfin-A , Dwarfin-A , Dwf-A, Dwf-A, Dwf-A , Dwf-A , JV4-1, JV4-1, JV4-1 , JV4-1 , MADH1, MADH1, MADH1 , MADH1 , MADR1, MADR1, MADR1 , MADR1 , Mad-related protein 1, Mad-related protein 1, Mad-related protein 1 , Mad-related protein 1 , Mad1, Mad1, Mad1 , Mad1 , Mothers against DPP homolog 1, Mothers against DPP homolog 1, Mothers against DPP homolog 1 , Mothers against DPP homolog 1 , Mothers against decapentaplegic homolog 1, Mothers against decapentaplegic homolog 1, Mothers against decapentapleg |
Gene, Accession # | UniProt: Q15797 |
Catalog # | abx031406 |
Price | please inquire |
Order / More Info | Mothers Against Decapentaplegic Homolog 1 (SMAD1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950