Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody from ABBEXA LTD
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| Antigenic Specificity | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | INPP5D antibody is a Rabbit polyclonal antibody against INPP5D. INPP5D, also named as SHIP, SHIP1, SIP-145 and hp51CN, belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family. INPP5D is phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. INPP5D acts as a negative regulator of B-cell antigen receptor signaling. It mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. INPP5D acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. INPP5D regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. It is involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. It is a key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. It modulates FCGR3/CD16-mediated cytotoxicity in NK cells. It mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. INPP5D may also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. |
| Immunogen | A synthetic peptide of human INPP5D. |
| Other Names | INPP5D, SHIP, SHIP1, Phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SH2 domain-containing inositol 5'-phosphatase 1, p150Ship, SHIP-1, hp51CN, SIP-145, INPP5D, INPP5D, INPP5D , INPP5D , SHIP, SHIP, SHIP , SHIP , SHIP1, SHIP1, SHIP1 , SHIP1 , Phosphatidylinositol 3, Phosphatidylinositol 3, Phosphatidylinositol 3 , Phosphatidylinositol 3 , 4, 4, 4 , 4 , 5-trisphosphate 5-phosphatase 1, 5-trisphosphate 5-phosphatase 1, 5-trisphosphate 5-phosphatase 1 , 5-trisphosphate 5-phosphatase 1 , Inositol polyphosphate-5-phosphatase of 145 kDa, Inositol polyphosphate-5-phosphatase of 145 kDa, Inositol polyphosphate-5-phosphatase of 145 kDa , Inositol polyphosphate-5-phosphatase of 145 kDa , SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol 5'-phosphatase 1 , SH2 domain-containing inositol 5'-phosphatase 1 , p150Ship, p150Ship, p150Ship , p150Ship , SHI |
| Gene, Accession # | INPP5D, Gene ID: 3635, UniProt: Q92835 |
| Catalog # | abx000561 |
| Price | please inquire |
| Order / More Info | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1 (INPP5D) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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