Caspase 8 (CASP8) Antibody from ABBEXA LTD
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| Antigenic Specificity | Caspase 8 (CASP8) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, mouse, monkey, rat |
| Isotype | IgG1 |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Alternative splicing of this gene results in five transcript variants. |
| Immunogen | Purified recombinant fragment of human CASP8 expressed in E. Coli. |
| Other Names | ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473, Caspase8, Apoptotic cysteine protease, Apoptotic protease Mch-5, Caspase-8 precursor, FADD-homologous ICE/CED-3- like protease, FADD-like ICE, ICE-like apoptotic protease 5, ICE8, MORT1-associated CED-3 homolog, FADD-homologous ICE/ced-3-like protease, CASP8, ALPS2B, ALPS2B, ALPS2B , ALPS2B , CAP4, CAP4, CAP4 , CAP4 , Casp-8, Casp-8, Casp-8 , Casp-8 , FLICE, FLICE, FLICE , FLICE , FLJ17672, FLJ17672, FLJ17672 , FLJ17672 , MACH, MACH, MACH , MACH , MCH5, MCH5, MCH5 , MCH5 , MGC78473, MGC78473, MGC78473 , MGC78473 , Caspase8, Caspase8, Caspase8 , Caspase8 , Apoptotic cysteine protease, Apoptotic cysteine protease, Apoptotic cysteine protease , Apoptotic cysteine protease , Apoptotic protease Mch-5, Apoptotic protease Mch-5, Apoptotic protease Mch-5 , Apoptotic protease Mch-5 , Caspase-8 precursor, Caspase-8 precursor, Caspase-8 precursor , Caspase-8 precursor , FADD-homologous ICE/CED-3- like protease, FADD-homolog |
| Gene, Accession # | Gene ID: 841, UniProt: Q14790 |
| Catalog # | abx012068 |
| Price | please inquire |
| Order / More Info | Caspase 8 (CASP8) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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