Edit |   |
---|---|
Antigenic Specificity | Dual Specificity Phosphatase 6 (DUSP6) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC, IF/ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene. |
Immunogen | KLH-conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6. |
Other Names | dual specificity protein phosphatase 6, dual specificity protein phosphatase PYST1, DUS6, DUSP6, MAP kinase phosphatase 3, mitogen-activated protein kinase phosphatase 3, MKP-3, MKP3, PYST1, HH19, dual specificity protein phosphatase 6, dual specificity protein phosphatase 6, dual specificity protein phosphatase 6 , dual specificity protein phosphatase 6 , dual specificity protein phosphatase PYST1, dual specificity protein phosphatase PYST1, dual specificity protein phosphatase PYST1 , dual specificity protein phosphatase PYST1 , DUS6, DUS6, DUS6 , DUS6 , DUSP6, DUSP6, DUSP6 , DUSP6 , MAP kinase phosphatase 3, MAP kinase phosphatase 3, MAP kinase phosphatase 3 , MAP kinase phosphatase 3 , mitogen-activated protein kinase phosphatase 3, mitogen-activated protein kinase phosphatase 3, mitogen-activated protein kinase phosphatase 3 , mitogen-activated protein kinase phosphatase 3 , MKP-3, MKP-3, MKP-3 , MKP-3 , MKP3, MKP3, MKP3 , MKP3 , PYST1, PYST1, PYST1 , PYST1 , HH19, HH19, |
Gene, Accession # | UniProt: Q16828 |
Catalog # | abx033959 |
Price | please inquire |
Order / More Info | Dual Specificity Phosphatase 6 (DUSP6) Antibody from ABBEXA LTD |
Product Specific References | n/a |
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950