2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody from ABBEXA LTD
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| Antigenic Specificity | 2'-5'-Oligoadenylate Synthetase 1 (OAS1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | 2'-5'-Oligoadenylate Synthetase 1 (OAS1) antibody is a Rabbit polyclonal antibody for the detection of OAS1. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. |
| Immunogen | 2',5'-oligoadenylate synthetase 1, 40/46kDa |
| Other Names | OAS1, 2'-5'-Oligoadenylate Synthetase 1, 2-5-Oligoadenylate Synthetase 1, 2-5-Oligoadenylate Synthetase 1, 40/46kDa, (2-5)Oligo(A) Synthase 1, 2-5A Synthase 1, E18/E16, OIAS, 2,5-Oligoadenylate Synthetase 1 (40-46 KD), 2-5-Oligoisoadenylate Synthetase 1, 2-5-Oligoadenylate Synthase 1, 2-5-Oligoadenylate Synthase 1, E16 (2-5) Oligo A Synthetase, 2,5-Oligo A Synthetase 1, 2-5A Synthetase 1, P46/P42 OAS, EC 2.7.7.84, IFI-4, OIASI, OAS1, OAS1, OAS1 , OAS1 , 2'-5'-Oligoadenylate Synthetase 1, 2'-5'-Oligoadenylate Synthetase 1, 2'-5'-Oligoadenylate Synthetase 1 , 2'-5'-Oligoadenylate Synthetase 1 , 2-5-Oligoadenylate Synthetase 1, 2-5-Oligoadenylate Synthetase 1, 2-5-Oligoadenylate Synthetase 1 , 2-5-Oligoadenylate Synthetase 1 , 2-5-Oligoadenylate Synthetase 1, 40/46kDa, 2-5-Oligoadenylate Synthetase 1, 40/46kDa, 2-5-Oligoadenylate Synthetase 1, 40/46kDa , 2-5-Oligoadenylate Synthetase 1, 40/46kDa , (2-5)Oligo(A) Synthase 1, (2-5)Oligo(A) Synthase 1, (2-5)Oligo(A) Synthase 1 , (2-5)Oli |
| Gene, Accession # | OAS1, Gene ID: 4938, UniProt: P00973 |
| Catalog # | abx240221 |
| Price | please inquire |
| Order / More Info | 2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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