Serine/threonine-Protein Kinase NLK (NLK) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Serine/threonine-Protein Kinase NLK (NLK) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Serine/threonine-Protein Kinase NLK (NLK) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. |
| Immunogen | Purified His-tagged Human NLK protein |
| Other Names | NLK, LAK1, Nemo-like kinase, Nmo kinase, Nemo like kinase, Protein LAK1, DKFZp761G1211, FLJ21033, Serine/threonine-protein kinase NLK, NLK, NLK, NLK , NLK , LAK1, LAK1, LAK1 , LAK1 , Nemo-like kinase, Nemo-like kinase, Nemo-like kinase , Nemo-like kinase , Nmo kinase, Nmo kinase, Nmo kinase , Nmo kinase , Nemo like kinase, Nemo like kinase, Nemo like kinase , Nemo like kinase , Protein LAK1, Protein LAK1, Protein LAK1 , Protein LAK1 , DKFZp761G1211, DKFZp761G1211, DKFZp761G1211 , DKFZp761G1211 , FLJ21033, FLJ21033, FLJ21033 , FLJ21033 , Serine/threonine-protein kinase NLK, Serine/threonine-protein kinase NLK, Serine/threonine-protein kinase NLK , Serine/threonine-protein kinase NLK |
| Gene, Accession # | NCBI: NP_057315.3, UniProt: Q9UBE8 |
| Catalog # | abx034924 |
| Price | please inquire |
| Order / More Info | Serine/threonine-Protein Kinase NLK (NLK) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies