Forkhead Box Protein O1 (FOXO1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Forkhead Box Protein O1 (FOXO1) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Forkhead Box Protein O1 (FOXO1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Forkhead Box Protein O1 (FOXO1) antibody is a Rabbit polyclonal antibody for the detection of FOXO1. Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. |
| Immunogen | forkhead box O1 |
| Other Names | Forkhead Box Protein O1, FOXO1, FOX-O1, FKH1, FKHR, FOXO1A, Forkhead Homolog In Rhabdomyosarcoma, Forkhead Box Protein O1, Forkhead Box Protein O1, Forkhead Box Protein O1 , Forkhead Box Protein O1 , FOXO1, FOXO1, FOXO1 , FOXO1 , FOX-O1, FOX-O1, FOX-O1 , FOX-O1 , FKH1, FKH1, FKH1 , FKH1 , FKHR, FKHR, FKHR , FKHR , FOXO1A, FOXO1A, FOXO1A , FOXO1A , Forkhead Homolog In Rhabdomyosarcoma, Forkhead Homolog In Rhabdomyosarcoma, Forkhead Homolog In Rhabdomyosarcoma , Forkhead Homolog In Rhabdomyosarcoma |
| Gene, Accession # | FOXO1, Gene ID: 2308, UniProt: Q12778 |
| Catalog # | abx010804 |
| Price | please inquire |
| Order / More Info | Forkhead Box Protein O1 (FOXO1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies