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Antigenic Specificity | Macrophage Inflammatory Protein 1 Beta (MIP1b) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MIP1b antibody is a Rabbit polyclonal antibody against MIP1b. Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1a, MIP-1?, MIP-2, MIP-3a, MIP-3?, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1? is more selective than MIP-1a, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1a is a more potent lymphocyte chemoattractant than MIP-1? and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1a has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1? and RANTES. Recombinant human MIP-1a acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner. |
Immunogen | A synthetic peptide of human CCL4. |
Other Names | Macrophage Inflammatory Protein 1 Beta, MIP1b, MIP-1, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta(1-69), Macrophage infl, CCL4, LAG1, ACT2, G-26, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta, MIP1-B, Chemokine C-C-Motif Ligand 4, Small Inducible Cytokine A4, Homologous To Mouse Mip-1b, Macrophage Inflammatory Protein 1 Beta, Macrophage Inflammatory Protein 1 Beta, Macrophage Inflammatory Protein 1 Beta , Macrophage Inflammatory Protein 1 Beta , MIP1b, MIP1b, MIP1b , MIP1b , MIP-1, MIP-1, MIP-1 , MIP-1 , C-C motif chemokine 4, C-C motif chemokine 4, C-C motif chemokine 4 , C-C motif chemokine 4 , G-26 T-lymphocyte-secreted protein, G-26 T-lymphocyte-secreted protein, G-26 T-lymphocyte-secreted protein , G-26 T-lymphocyte-secreted protein , HC21, HC21, HC21 , HC21 , Lymphocyte activation gene 1 protein, Lymphocyte activation gene 1 protein, Lymphocyte activation gene 1 protein , Lymphocyte activation ge |
Gene, Accession # | CCL4, Gene ID: 6351, UniProt: P13236 |
Catalog # | abx001404 |
Price | please inquire |
Order / More Info | Macrophage Inflammatory Protein 1 Beta (MIP1b) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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