Lysine-Specific Histone Demethylase 1A (LSD1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Lysine-Specific Histone Demethylase 1A (LSD1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. |
| Immunogen | KLH-conjugated synthetic peptide between 457-490 amino acids from the Central region of human LSD1. |
| Other Names | KDM1A, AOF2, KDM1, KIAA0601, LSD1, BHC110, CPRF, Lysine Demethylase 1A, BRAF35-HDAC Complex Protein BHC110, Lysine-Specific Histone Demethylase 1A, Lysine-Specific Histone Demethylase 1, Lysine (K)-Specific Demethylase 1A, Lysine (K)-Specific Demethylase 1, KDM1A, KDM1A, KDM1A , KDM1A , AOF2, AOF2, AOF2 , AOF2 , KDM1, KDM1, KDM1 , KDM1 , KIAA0601, KIAA0601, KIAA0601 , KIAA0601 , LSD1, LSD1, LSD1 , LSD1 , BHC110, BHC110, BHC110 , BHC110 , CPRF, CPRF, CPRF , CPRF , Lysine Demethylase 1A, Lysine Demethylase 1A, Lysine Demethylase 1A , Lysine Demethylase 1A , BRAF35-HDAC Complex Protein BHC110, BRAF35-HDAC Complex Protein BHC110, BRAF35-HDAC Complex Protein BHC110 , BRAF35-HDAC Complex Protein BHC110 , Lysine-Specific Histone Demethylase 1A, Lysine-Specific Histone Demethylase 1A, Lysine-Specific Histone Demethylase 1A , Lysine-Specific Histone Demethylase 1A , Lysine-Specific Histone Demethylase 1, Lysine-Specific Histone Demethylase 1, Lysine-Specific Histone Demethylase 1 , L |
| Gene, Accession # | UniProt: O60341 |
| Catalog # | abx026647 |
| Price | please inquire |
| Order / More Info | Lysine-Specific Histone Demethylase 1A (LSD1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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