Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha (PIP5K1A) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha (PIP5K1A) antibody, protein, ELISA kits.
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| Antigenic Specificity | Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha (PIP5K1A) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP (2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P (4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis. |
| Immunogen | KLH-conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human PIP5K1A. |
| Other Names | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, PIP5K1-alpha, PtdIns(4)P-5-kinase 1 alpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, Phosphatidylinositol 4-phosphate 5-kinase type I alpha, PIP5KIalpha, PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha , Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha , PIP5K1-alpha, PIP5K1-alpha, PIP5K1-alpha , PIP5K1-alpha , PtdIns(4)P-5-kinase 1 alpha, PtdIns(4)P-5-kinase 1 alpha, PtdIns(4)P-5-kinase 1 alpha , PtdIns(4)P-5-kinase 1 alpha , 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha , 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha , Phosphatidylinositol 4-phosphate 5-kinase |
| Gene, Accession # | NCBI: NP_001129108.1, NP_001129109.1, NP_001129110.1, NP_003548.1, UniProt: Q99755 |
| Catalog # | abx033836 |
| Price | please inquire |
| Order / More Info | Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha (PIP5K1A) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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