Denticleless Protein Homolog (DTL) Antibody from ABBEXA LTD
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| Antigenic Specificity | Denticleless Protein Homolog (DTL) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Denticleless Protein Homolog (DTL) antibody is a Rabbit polyclonal antibody for the detection of DTL. Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX (DTL) complex, also named CRL4 (CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21 (CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21 (CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX (DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX (DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). |
| Immunogen | denticleless homolog(Drosophila) |
| Other Names | DTL, Denticleless E3 Ubiquitin Protein Ligase Homolog, Retinoic Acid-Regulated Nuclear Matrix-Associated Protein, Lethal(2) Denticleless Protein Homolog, DDB1- And CUL4-Associated Factor 2, DCAF2, L2DTL, CDT2, RAMP, DTL, DTL, DTL , DTL , Denticleless E3 Ubiquitin Protein Ligase Homolog, Denticleless E3 Ubiquitin Protein Ligase Homolog, Denticleless E3 Ubiquitin Protein Ligase Homolog , Denticleless E3 Ubiquitin Protein Ligase Homolog , Retinoic Acid-Regulated Nuclear Matrix-Associated Protein, Retinoic Acid-Regulated Nuclear Matrix-Associated Protein, Retinoic Acid-Regulated Nuclear Matrix-Associated Protein , Retinoic Acid-Regulated Nuclear Matrix-Associated Protein , Lethal(2) Denticleless Protein Homolog, Lethal(2) Denticleless Protein Homolog, Lethal(2) Denticleless Protein Homolog , Lethal(2) Denticleless Protein Homolog , DDB1- And CUL4-Associated Factor 2, DDB1- And CUL4-Associated Factor 2, DDB1- And CUL4-Associated Factor 2 , DDB1- And CUL4-Associated Factor 2 , DCAF2, D |
| Gene, Accession # | DTL, Gene ID: 51514, UniProt: Q9NZJ0 |
| Catalog # | abx240101 |
| Price | please inquire |
| Order / More Info | Denticleless Protein Homolog (DTL) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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