STEP/PTPN5 Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-STEP/PTPN5 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | STEP/PTPN5 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90% identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons. |
| Immunogen | KLH-conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5. |
| Other Names | PTPN5, Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase, PTPN5, PTPN5, PTPN5 , PTPN5 , Tyrosine-protein phosphatase non-receptor type 5, Tyrosine-protein phosphatase non-receptor type 5, Tyrosine-protein phosphatase non-receptor type 5 , Tyrosine-protein phosphatase non-receptor type 5 , Neural-specific protein-tyrosine phosphatase, Neural-specific protein-tyrosine phosphatase, Neural-specific protein-tyrosine phosphatase , Neural-specific protein-tyrosine phosphatase , Striatum-enriched protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase , Striatum-enriched protein-tyrosine phosphatase |
| Gene, Accession # | NCBI: NP_001035059.1, NP_001265165.1, NP_001265167.1, NP_001265168.1, NP_008837.1, NP_116170.3, UniProt: P54829 |
| Catalog # | abx033947 |
| Price | please inquire |
| Order / More Info | STEP/PTPN5 Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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