Retinoic Acid Receptor Alpha (RARA) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Retinoic Acid Receptor Alpha (RARA) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Retinoic Acid Receptor Alpha (RARA) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | RARA antibody is a Rabbit polyclonal antibody against RARA. Retinoids (vitamin A and its active retinoic acid derivatives) are non-steroid hormones that regulate cell prolifeRation, differentiation and apoptosisRetinoic acid receptors (RARalpha, -beta and -gamma) and retinoid X receptors (RXRalpha, -beta and -gamma) are nuclear receptors that function as RAR-RXR heterodimers or RXR homodimersIn response to retinoid binding, these dimers control gene expression by binding to specific retinoic acid response elements, by recruiting cofactors and the transcriptional machinery, and by indirectly regulating chromatin structureFinally, ligand binding and phosphorylation of RARalpha by JNK at Thr181, Ser445 and Ser461 controls the stability of RAR-RXR through the ubiquitin-proteasome pathwayAt least four distinct genetic lesions affect RARalpha and result in acute promyelocytic leukemia (APL)The t(15;17) translocation that results in the PML-RARalpha fusion protein is responsible for more than 99% of APL cases, and the fusion protein inhibits PML-dependent apoptotic pathways in a dominant negative fashionIn addition PML-RARalpha inhibits transcription of retinoic acid target genes by recruiting co-repressors, attenuating myeloid differentiation. |
| Immunogen | Recombinant protein of human RAR?. |
| Other Names | RARA, NR1B1, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, RAR alpha, retinoic acid receptor, alpha, RAR, retinoic acid receptor, alpha, Retinoic acid receptor, alpha polypeptide, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR short form, RARA, RARA, RARA , RARA , NR1B1, NR1B1, NR1B1 , NR1B1 , Retinoic acid receptor alpha, Retinoic acid receptor alpha, Retinoic acid receptor alpha , Retinoic acid receptor alpha , Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group B member 1 , Nuclear receptor subfamily 1 group B member 1 , RAR alpha, RAR alpha, RAR alpha , RAR alpha , retinoic acid receptor, retinoic acid receptor, retinoic acid receptor , retinoic acid receptor , alpha, alpha, alpha , alpha , RAR, RAR, RAR , RAR , retinoic acid receptor, alpha, retinoic acid receptor, alpha, |
| Gene, Accession # | RARA, Gene ID: 5914, UniProt: P10276 |
| Catalog # | abx117006 |
| Price | please inquire |
| Order / More Info | Retinoic Acid Receptor Alpha (RARA) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies