Edit |   |
---|---|
Antigenic Specificity | HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
Immunogen | KLH-conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB. |
Other Names | HLA-DMB, D6S221E, DMB, MHC class II antigen DMB, MHC class II HLA-DMB, RING7, HLA class II histocompatibility antigen, DM beta chain, Really interesting new gene 7 protein, HLA-DMB, HLA-DMB, HLA-DMB , HLA-DMB , D6S221E, D6S221E, D6S221E , D6S221E , DMB, DMB, DMB , DMB , MHC class II antigen DMB, MHC class II antigen DMB, MHC class II antigen DMB , MHC class II antigen DMB , MHC class II HLA-DMB, MHC class II HLA-DMB, MHC class II HLA-DMB , MHC class II HLA-DMB , RING7, RING7, RING7 , RING7 , HLA class II histocompatibility antigen, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen , HLA class II histocompatibility antigen , DM beta chain, DM beta chain, DM beta chain , DM beta chain , Really interesting new gene 7 protein, Really interesting new gene 7 protein, Really interesting new gene 7 protein , Really interesting new gene 7 protein |
Gene, Accession # | HLA-DMB, UniProt: P28068 |
Catalog # | abx028893 |
Price | please inquire |
Order / More Info | HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) Antibody from ABBEXA LTD |
Product Specific References | n/a |
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950