Recombination Activating Gene 2 (RAG2) Antibody from ABBEXA LTD
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| Antigenic Specificity | Recombination Activating Gene 2 (RAG2) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This gene encodes a protein that is involved in the initiation of V (D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. |
| Immunogen | Purified recombinant fragment of human RAG2 (350-527aa) expressed in E. Coli. |
| Other Names | RAG-2, RAG2, V (D) J recombination-activating protein 2, RAG-2, RAG-2, RAG-2 , RAG-2 , RAG2, RAG2, RAG2 , RAG2 , V (D) J recombination-activating protein 2, V (D) J recombination-activating protein 2, V (D) J recombination-activating protein 2 , V (D) J recombination-activating protein 2 |
| Gene, Accession # | RAG2, Gene ID: 5897, UniProt: P55895 |
| Catalog # | abx012073 |
| Price | please inquire |
| Order / More Info | Recombination Activating Gene 2 (RAG2) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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