ganglioside GD2 (Dinutuximab biosimilar) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-ganglioside GD2 (Dinutuximab biosimilar) antibody, protein, ELISA kits.
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| Antigenic Specificity | ganglioside GD2 (Dinutuximab biosimilar) |
| Clone | monoclonal |
| Host Species | Chimeric Human/Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein A/G purified |
| Size | 100 µg, 1 mg, |
| Concentration | typically between 0.5-2.0 mg/ml. |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Dinutuximab is a monoclonal antibody biosimilar expressed in CHO cells, targeting ganglioside GD2, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14. 18 and the constant regions of human IgG1 heavy-chain and kappa light-chain. By binding to GD2, dinutiximab induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity of tumor cells thereby leading to apoptosis and inhibiting proliferation of the tumour. It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse. |
| Immunogen | n/a |
| Other Names | Dinutuximab, ganglioside GD2, 1363687-32-4 |
| Gene, Accession # | CAS: 1363687-32-4 |
| Catalog # | abx831281 |
| Price | please inquire |
| Order / More Info | ganglioside GD2 (Dinutuximab biosimilar) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
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Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
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Telephone: +1 832 327 7413
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Telephone: +44 (0) 1223 755950
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