Death Domain Associated Protein / DAP6 (DAXX) Antibody from ABBEXA LTD
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| Antigenic Specificity | Death Domain Associated Protein / DAP6 (DAXX) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µl, |
| Concentration | 1 mg/ml |
| Applications | ELISA, WB, IF/ICC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF beta R2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF beta R2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described. |
| Immunogen | Purified recombinant fragment of human DAXX expressed in E. Coli. |
| Other Names | BING2, DAP6, Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein, ETS1 associated protein 1, Fas DEATH domain- associated protein, BING2, BING2, BING2 , BING2 , DAP6, DAP6, DAP6 , DAP6 , Death domain-associated protein 6, Death domain-associated protein 6, Death domain-associated protein 6 , Death domain-associated protein 6 , Daxx, Daxx, Daxx , Daxx , hDaxx, hDaxx, hDaxx , hDaxx , ETS1-associated protein 1, ETS1-associated protein 1, ETS1-associated protein 1 , ETS1-associated protein 1 , EAP1, EAP1, EAP1 , EAP1 , Fas death domain-associated protein, Fas death domain-associated protein, Fas death domain-associated protein , Fas death domain-associated protein , ETS1 associated protein 1, ETS1 associated protein 1, ETS1 associated protein 1 , ETS1 associated protein 1 , Fas DEATH domain- associated protein, Fas DEATH domain- associated protein, Fas DEATH domain- associated protein , Fas DEATH domain- associated |
| Gene, Accession # | DAXX, Gene ID: 1616, UniProt: Q9UER7 |
| Catalog # | abx010630 |
| Price | please inquire |
| Order / More Info | Death Domain Associated Protein / DAP6 (DAXX) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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