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Antigenic Specificity | V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 100 µg, |
Concentration | 2 mg/ml |
Applications | ELISA, WB, IHC, IF/ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA) antibody is a Rabbit polyclonal antibody for the detection of p65/RELA. Nuclear factor k B (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-Kb family in mammalian cells include the proto-oncogene c-Rel,p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-Kb. The p65 subunit is a major component of NF-Kb complexes and is responsible for trans-activation. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. It associates with chromatin at the NF-kappa-B promoter region via association with DDX1. |
Immunogen | v-rel reticuloendotheliosis viral oncogene homolog A(avian) |
Other Names | RELA, V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, NFKB3, p65, REL-A, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3, Transcription Factor P65, Nuclear factor NF-kappa-B p65 subunit, RELA, RELA, RELA , RELA , V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, V-Rel Reticuloendotheliosis Viral Oncogene Homolog A , V-Rel Reticuloendotheliosis Viral Oncogene Homolog A , NFKB3, NFKB3, NFKB3 , NFKB3 , p65, p65, p65 , p65 , REL-A, REL-A, REL-A , REL-A , Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 , Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3 , Transcription Factor P65, Transcription Factor P65, Transcription Factor P65 , Transcription Factor P65 , Nuclear factor NF-kappa-B p65 subunit, Nuclear factor NF-kappa-B |
Gene, Accession # | RELA, Gene ID: 5970, UniProt: Q04206 |
Catalog # | abx011267 |
Price | please inquire |
Order / More Info | V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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