Heat Shock 70 kDa Protein 5 (HSPA5) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Heat Shock 70 kDa Protein 5 (HSPA5) antibody, protein, ELISA kits.
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| Antigenic Specificity | Heat Shock 70 kDa Protein 5 (HSPA5) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) (PubMed 8020977) pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.The HSP70 proteins are ubiquitous molecular chaparones that are found in all organisms and tissue types. Like other members of the HSP70 family, BiP is a peptide-binding ATPase that is able to differentiate native proteins from unfolded polypeptides. BiP does not bind to fully folded and assembled proteins, except in the presence of other co-chaparones. BiP is involved in a number of key mechanisms and pathways including polypeptide translocation across the endoplasmic reticulum, folding, assembly, transport of secreted or membrane proteins, and the regulation of calcium homeostasis. Although BiP is relatively abundant, marked increases in BiP occur where there is an accumulation of unfolded polypeptides. For this reason, BiP has been identified as a marker for various disease states that are associated with secretory and transmembrane protein misfolding. |
| Immunogen | Purified recombinant fragment of human HSPA5 expressed in E. Coli. |
| Other Names | 78 kDa glucose-regulated proteinGRP-78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP, Hspa5, Grp78, MIF2, FLJ26106, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, HEL-S-89n, GRP-78, Epididymis Secretory Sperm Binding Protein Li 89n, Heat Shock 70kDa Protein 5, Glucose-Regulated Protein, 78kDa, Glucose Regulated Protein, Glucose Regulated Protein 78, Binding Immunoglobulin Protein, Endoplasmic reticulum lumenal Ca binding grp78, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), GRP78,BIP, 78 kDa glucose-regulated protein, Endoplasmic reticulum lumenal Ca (2+) binding protein grp78, 78 kDa glucose-regulated proteinGRP-78, 78 kDa glucose-regulated proteinGRP-78, 78 kDa glucose-regulated proteinGRP-78 , 78 kDa glucose-regulated proteinGRP-78 , Heat shock 70 kDa protein 5, Heat shock 70 kDa protein 5, Heat shock 70 kDa protein 5 , Heat shock 70 kDa protein 5 , Immunoglobulin heavy chain-binding protein, Immunoglobulin heavy chain- |
| Gene, Accession # | HSPA5, Gene ID: 3309, UniProt: P11021 |
| Catalog # | abx012357 |
| Price | please inquire |
| Order / More Info | Heat Shock 70 kDa Protein 5 (HSPA5) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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