Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN (PTEN) Antibody from ABBEXA LTD
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| Antigenic Specificity | Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN (PTEN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PTEN, (phosphatase and tensin homolog deleted on chromosome 10), also known as MMAC1 (mutated in multiple advanced cancers 1), is a tumor suppressor implicated in a large number of human tumors. The PTEN phosphatase incorporates the catalytic motif (HCXXGXXRS/T) that is a signature of the protein tyrosine phosphatase family. Recombinant human PTEN is a dual phosphatase with ability to dephosphorylate both tyrosine and serine/threonine residues. PTEN functions primarily as a lipid phosphatase to regulate signal transduction pathways, with a primary target identified as phosphatidylinositol 3, 4, 5 trisphosphate. In addition, PTEN presents weak tyrosine phosphatase activity, which may downregulate signaling pathways involving focal adhesion kinase or Shc. PTEN negatively regulates activation of the serine/threonine kinase Akt/PKB by blocking its phosphorylation, thereby inhibiting the PI 3 kinase Akt signaling pathway, which is important for cell survival. In vivo, the majority of PTEN missense mutations detected in tumor specimens target the phosphatase domain and cause a loss in PTEN phosphatase activity. Mutations in PTEN are associated with several common cancers including prostate, brain and breast cancer, and with Cowden's disease, an autosomal dominant disorder conferring susceptibility to benign and malignant tumors. Germline mutations of PTEN are also linked Lhermitte-Duclos disease and Bannayan-Zonana syndrome. Mutations of PTEN occur in 60 to 80% of prostate cancers. PTEN is also essential for embryonic development. |
| Immunogen | KLH-conjugated synthetic peptide between 69-104 amino acids from the N-terminal region of human PTEN. |
| Other Names | 10q23del, BZS, DEC, MGC11227, MHAM, MMAC1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PTEN, PTEN1, TEP1, GLM2, Platelet antigen BR, PTEN 1, Tensin homolog, TEP 1, VLA 2 Receptor Alpha Subunit, PTEN (Phospho-Ser370), Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, Mitochondrial Phosphatase And Tensin Protein Alpha, Mitochondrial Phosphatase And Tensin Protein , Phosphatase And Tensin-Like Protein, Mitochondrial PTENalpha, Mitochondrial PTEN alpha, Mitochondrial PTEN, Mitochondrial PTEN , CWS1, Phosphatidylinositol 345-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, Phosphatidylinositol-345-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, 10q23del, 10q23del, 10q23del , 10q23del , BZS, BZ |
| Gene, Accession # | PTEN, NCBI: NP_000305.3, UniProt: P60484 |
| Catalog # | abx033952 |
| Price | please inquire |
| Order / More Info | Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN (PTEN) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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