MutL Homolog 1 (MLH1) Antibody from ABBEXA LTD
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| Antigenic Specificity | MutL Homolog 1 (MLH1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MLH1 antibody is a Rabbit polyclonal antibody against MLH1. Mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. MLH1 is the human homologue of the E. coli MMR gene mutL. MMR requires recognition of a base mismatch or insertion/deletion loop by a MutS homolog followed by recruitment of a MutL heterodimeric complex consisting of MLH1 and PMS1 (MutL-?), PMS2 (MutL-?) or MLH3 (MutL-?). Other factors required for MMR in eukaryotes are EXO1, PCNA, RFC, RPA, DNA polymerases and DNA ligase (reviewed in 1). Inactivation of the MLH1 gene causes genome instability and predisposition to cancer (2-5). The MLH1 gene is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) (6). MLH1 also plays a role in meiotic recombination (7). 1.Modrich, P. (2006) J Biol Chem 281, 30305-9. 2.Seng, T.J. et al. (2008) Br J Cancer 99, 375-82. 3.Harley, I. et al. (2008) Gynecol Oncol 109, 384-7. 4.Mao, G. et al. (2008) J Biol Chem 283, 3211-6. 5.Hubner, R.A. and Houlston, R.S. (2007) J Natl Cancer Inst 99, 1490; author reply 1490-1. 6.Vasen, H.F. (2005) Fam Cancer 4, 219-25. 7.Argueso, J.L. et al. (2003) Mol Cell Biol 23, 873-86. |
| Immunogen | Recombinant protein of human MLH1. |
| Other Names | DNA mismatch repair protein Mlh1, MutL protein homolog 1, COCA2, MLH1, FCC2, HNPCC, hMLH1, HNPCC2, MGC5172, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), DNA mismatch repair protein Mlh1, DNA mismatch repair protein Mlh1, DNA mismatch repair protein Mlh1 , DNA mismatch repair protein Mlh1 , MutL protein homolog 1, MutL protein homolog 1, MutL protein homolog 1 , MutL protein homolog 1 , COCA2, COCA2, COCA2 , COCA2 , MLH1, MLH1, MLH1 , MLH1 , FCC2, FCC2, FCC2 , FCC2 , HNPCC, HNPCC, HNPCC , HNPCC , hMLH1, hMLH1, hMLH1 , hMLH1 , HNPCC2, HNPCC2, HNPCC2 , HNPCC2 , MGC5172, MGC5172, MGC5172 , MGC5172 , mutL homolog 1, mutL homolog 1, mutL homolog 1 , mutL homolog 1 , colon cancer, colon cancer, colon cancer , colon cancer , nonpolyposis type 2 (E. coli), nonpolyposis type 2 (E. coli), nonpolyposis type 2 (E. coli) , nonpolyposis type 2 (E. coli) |
| Gene, Accession # | MLH1, Gene ID: 4292, UniProt: P40692 |
| Catalog # | abx000639 |
| Price | please inquire |
| Order / More Info | MutL Homolog 1 (MLH1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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