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Antigenic Specificity | DAXX (pS213) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. |
Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human DAXX. |
Other Names | BING2, DAP6, Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein, ETS1 associated protein 1, Fas DEATH domain- associated protein, BING2, BING2, BING2 , BING2 , DAP6, DAP6, DAP6 , DAP6 , Death domain-associated protein 6, Death domain-associated protein 6, Death domain-associated protein 6 , Death domain-associated protein 6 , Daxx, Daxx, Daxx , Daxx , hDaxx, hDaxx, hDaxx , hDaxx , ETS1-associated protein 1, ETS1-associated protein 1, ETS1-associated protein 1 , ETS1-associated protein 1 , EAP1, EAP1, EAP1 , EAP1 , Fas death domain-associated protein, Fas death domain-associated protein, Fas death domain-associated protein , Fas death domain-associated protein , ETS1 associated protein 1, ETS1 associated protein 1, ETS1 associated protein 1 , ETS1 associated protein 1 , Fas DEATH domain- associated protein, Fas DEATH domain- associated protein, Fas DEATH domain- associated protein , Fas DEATH domain- associated |
Gene, Accession # | UniProt: Q9UER7 |
Catalog # | abx031856 |
Price | please inquire |
Order / More Info | DAXX (pS213) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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