H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody from ABBEXA LTD
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| Antigenic Specificity | H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DKC1 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. |
| Immunogen | KLH-conjugated synthetic peptide between 185-213 amino acids from the Central region of human DKC1. |
| Other Names | DKC1, DKC, CBF5, DKCX, NAP57, NOLA4, XAP101, dyskeratosis congenita 1, dyskerin, H/ACA ribonucleoprotein complex subunit 4, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, DKC1, DKC1, DKC1 , DKC1 , DKC, DKC, DKC , DKC , CBF5, CBF5, CBF5 , CBF5 , DKCX, DKCX, DKCX , DKCX , NAP57, NAP57, NAP57 , NAP57 , NOLA4, NOLA4, NOLA4 , NOLA4 , XAP101, XAP101, XAP101 , XAP101 , dyskeratosis congenita 1, dyskerin, dyskeratosis congenita 1, dyskerin, dyskeratosis congenita 1, dyskerin , dyskeratosis congenita 1, dyskerin , H/ACA ribonucleoprotein complex subunit 4, H/ACA ribonucleoprotein complex subunit 4, H/ACA ribonucleoprotein complex subunit 4 , H/ACA ribonucleoprotein complex subunit 4 , CBF5 homolog, CBF5 homolog, CBF5 homolog , CBF5 homolog , Dyskerin, Dyskerin, Dyskerin , Dyskerin , Nopp140-associated protein of 57 kDa, Nopp140-associated protein of 57 kDa, Nopp140-associated protein of |
| Gene, Accession # | DKC1, UniProt: O60832 |
| Catalog # | abx032535 |
| Price | please inquire |
| Order / More Info | H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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