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Antigenic Specificity | Sorting Nexin 6 (SNX6) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, 2, 4, and 6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases. |
Immunogen | Human SNX6 recombinant protein. |
Other Names | SNX6, Sorting nexin-6, TRAF4-associated factor 2, SNX6, SNX6, SNX6 , SNX6 , Sorting nexin-6, Sorting nexin-6, Sorting nexin-6 , Sorting nexin-6 , TRAF4-associated factor 2, TRAF4-associated factor 2, TRAF4-associated factor 2 , TRAF4-associated factor 2 |
Gene, Accession # | SNX6, UniProt: Q9UNH7 |
Catalog # | abx028206 |
Price | please inquire |
Order / More Info | Sorting Nexin 6 (SNX6) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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