Suppressor Of Ty 6 Homolog (SUPT6H) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Suppressor Of Ty 6 Homolog (SUPT6H) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Suppressor Of Ty 6 Homolog (SUPT6H) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Suppressor Of Ty 6 Homolog (SUPT6H) antibody is a Rabbit polyclonal antibody for the detection of SUPT6H. Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. |
| Immunogen | suppressor of Ty 6 homolog(S. cerevisiae) |
| Other Names | Suppressor Of Ty 6 Homolog, SUPT6H, SPT6, SPT6H, emb-5, Histone chaperone suppressor of Ty6, Tat-cotransactivator 2 protein, Transcription elongation factor SPT6, Suppressor Of Ty 6 Homolog, Suppressor Of Ty 6 Homolog, Suppressor Of Ty 6 Homolog , Suppressor Of Ty 6 Homolog , SUPT6H, SUPT6H, SUPT6H , SUPT6H , SPT6, SPT6, SPT6 , SPT6 , SPT6H, SPT6H, SPT6H , SPT6H , emb-5, emb-5, emb-5 , emb-5 , Histone chaperone suppressor of Ty6, Histone chaperone suppressor of Ty6, Histone chaperone suppressor of Ty6 , Histone chaperone suppressor of Ty6 , Tat-cotransactivator 2 protein, Tat-cotransactivator 2 protein, Tat-cotransactivator 2 protein , Tat-cotransactivator 2 protein , Transcription elongation factor SPT6, Transcription elongation factor SPT6, Transcription elongation factor SPT6 , Transcription elongation factor SPT6 |
| Gene, Accession # | UniProt: Q7KZ85 |
| Catalog # | abx240100 |
| Price | please inquire |
| Order / More Info | Suppressor Of Ty 6 Homolog (SUPT6H) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies