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Antigenic Specificity | ASAP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | unconjugated |
Size | 100 µg |
Concentration | 1.09 mg/mL |
Applications | ELISA, Immunohistochemistry, Western Blotting |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. ASAP1 (also known as AMAP1, 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein, PIP2-dependent ARF1 GAP,ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, Differentiation-enhancing factor 1, DEF-1) is an Arf-directed GTPase activating protein that is a substrate for the kinases Src and FAK and has been implicated in the regulation of membrane traffic, focal adhesions and invadopodia/podosomes. Phosphorylation of ASAP1 at tyrosine 782 has been found to affect enzymatic and some biological activities, including the function of invadopodia. ASAP1 is expressed in many tissues but is most abundant in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. Multiple transcript variants have been reported for this protein.Target Information: This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. |
Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 777-787 of mouse ASAP1 protein. |
Other Names | AV239055|DEF-1|Ddef1|PAP|mKIAA1249|s19|130 kDa phosphatidylinositol 4|5-biphosphate-dependent ARF1 GTPase-activating protein|5-bisphosphate-dependent ARF1 GTPase-activating protein|ADP-ribosylation factor-directed GTPase-activating protein 1|ARF GTPase-activating protein 1|PIP2-dependent ARF1 GAP|arf-GAP with SH3 domain|ANK repeat and PH domain-containing protein 1|development and differentiation-enhancing factor 1|ArfGAP with SH3 domain, ankyrin repeat and PH domain1|Asap1|ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1|AMAP1|CENTB4|PAG2|ZG14P|centaurin|beta 4|toxic extracellular endopeptidase|development and differentiation enhancing factor 1|differentiation-enhancing factor 1|ArfGAP with SH3 domain|ankyrin repeat and PH domain 1|ANK repeat and PH domain-containing protein 1-like|ankyrin repeat and PH domain1|ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 L homeolog|asap1.L|si:ch211-160i2.3|ankyrin repeat and PH domain 1a|ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a|asap1a |
Gene, Accession # | Gene ID: 13196 |
Catalog # | ABIN129669 |
Price | $537 |
Order / More Info | ASAP1 Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | n/a |