HMGN1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | HMGN1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.20 mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. HMGNs are proteins that bind chromatin effectively reducing the compaction of the chromatin fiber and enhancing access to DNA regulatory sequences. Members of this family have a conserved chromatin binding domain which is phosphorylated during mitosis. The sequence immunized is conserved in several species. As such, this reagent is designed as a ''universal'' reagent for the detection of all phosphorylated HMGN proteins. The High Mobility Group (HMG) proteins were originally isolated from mammalian cells and were named according to their electrophoretic mobility in polyacrylamide gels. HMGs were arbitrarily classed as a specific type of nonhistone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. HMG proteins and are now subdivided into 3 families: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family. Each HMG family has a characteristic functional sequence motif. The functional motif of the HMGB family is called the ''HMG-box,'' that of the HMGN family, the ''nucleosomal binding domain,'' and that of the HMGA family, the ''AT-hook.'' The functional motifs characteristic of these canonical HMGs are widespread among nuclear proteins in a variety of organisms. Proteins containing any of these functional motifs embedded in their sequence are known as ''HMG motif proteins.''Target Information: The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 19-28 of human HMGN protein (see below). |
| Other Names | HMG14|high mobility group nucleosome-binding domain-containing protein 1|high-mobility group (nonhistone chromosomal) protein 14|high-mobility group nucleosome binding 1|high-mobility group nucleosome binding domain 1|non-histone chromosomal protein HMG-14|nonhistone chromosomal protein HMG-14|high mobility group nucleosome binding domain 1|HMGN1|hmgn1b|high-mobility group nucleosome binding domain 1 b|high mobility group nucleosome binding domain 1 S homeolog|hmgn1.S|HMG-14|high mobility group protein 14|high-mobility group nucleosome-binding domain-containing protein 1|high mobility group nucleosomal binding domain 1|HMG-14 protein|non-histone chromosomal protein HMG-14B|LOC785479 |
| Gene, Accession # | Gene ID: 3150 |
| Catalog # | ABIN129664 |
| Price | $537 |
| Order / More Info | HMGN1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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