CD4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD4 |
| Clone | GK1-5 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b kappa |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | 200 µg/mL |
| Applications | Coating, ELISA, Flow Cytometry, Immunofluorescence, Neutralization |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD4 is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosine kinase, lck. CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines. Target Information: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]. |
| Immunogen | Mouse CTL clone V4 |
| Other Names | CD4mut|CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4Leu-3|T-cell surface glycoprotein CD4|CD4 molecule|CD4|W325|p55|CD4 antigen|W325 antigen|L3T4|Ly-4|T-cell differentiation antigen L3T4|T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4Leu-3) (T-cell differentiation antigen L3T4)|carcinoembryonic antigen-related cell adhesion molecule 5|LOC100125525|lymphocyte antigen CD4|cell surface glycoprotein CD4|cd1|cd11|cd12|cd19|cd2|cd23|cd5|cd6|cd9|ighv1s1|ighv1s3|ighv1s4|immunoglobulin heavy variable 1 subgroup 1|immunoglobulin heavy variable 1 subgroup 3|immunoglobulin heavy variable 1 subgroup 4|immunoglobulin heavy variable 1-1|ighv1-1 |
| Gene, Accession # | Gene ID: 920, 12504 |
| Catalog # | ABIN6933685 |
| Price | $274 |
| Order / More Info | CD4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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