Granulin Antibody from ANTIBODIES-ONLINE GmbH

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Antigenic SpecificityGranulin
Clonepolyclonal
Host SpeciesGuinea Pig
Reactive Specieshuman
Isotypen/a
Formatunconjugated
Size100 µg
Concentration1 mg/mL
ApplicationsELISA, Immunohistochemistry, Western Blotting
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DescriptionProduct Characteristics: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.Target Information: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
ImmunogenRecombinant human progranulin.
Other NamesCLN11|GEP|GP88|PCDGF|PEPI|PGRN|PC cell-derived growth factor|acrogranin|granulin-epithelin|granulins|proepithelin|progranulin|granulin precursor|GRN|Granulin|wu:fb11g12|wu:fj18f05|granulin-a|zfPGRN-A|granulin a|grna|epithelin|acrogranulin|MGC53354|granulin L homeolog|grn.L|ORF1 granulin|DKFZp459H066|Matrix protein|ORF1
Gene, Accession #Gene ID: 2896
Catalog #ABIN1169391
Price$444.94
Order / More InfoGranulin Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155

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