PIEZO1 Antibody from ANTIBODIES-ONLINE GmbH

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Antigenic SpecificityPIEZO1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatunconjugated
Size100 µL
Concentrationn/a
ApplicationsImmunohistochemistry, Western Blotting
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DescriptionProduct Characteristics: FUNCTION: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Overexpression in multiple cell lines generates robust mechanosensitive cation currents that are non-selective, exhibit a linear current voltage relationship, and are sensitive to ruthenium red and gadolinium. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane, Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane, Multi-pass membrane protein Tissue specificity: Expressed in bladder, colon, kidney, lung, and skin.Synonyms: Piezo type mechanosensitive ion channel component 1, PIEZO1Target Information: Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010].
ImmunogenA synthetic peptide from aa region 1350-1400 of human FAM38A conjugated to blue carrier protein was used as the antigen.
Other NamesDHS|FAM38A|Mib|family with sequence similarity 38|member A|membrane protein induced by beta-amyloid treatment|protein PIEZO1|piezo type mechanosensitive ion channel component 1|PIEZO1|Piezo-Type Mechanosensitive Ion Channel Component 1|9630020g22|mKIAA0233
Gene, Accession #Gene ID: 9780
Catalog #ABIN1842123
Price$454.67
Order / More InfoPIEZO1 Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155

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