ASAP3 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | ASAP3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Anti-UPLC1 (up-regulated in liver cancer 1) / ASAP3 Antibody, also named DDEFL1 (development and differentiation-enhancing factor-like 1) or ASAP3, is a member of the AZAP family of proteins. These proteins catalyze the hydrolysis of GTP bound to ADP-ribosylation factor (Arf) proteins, thereby causing Arf inactivation. For this reason, the ASAPs are generally called ArfGAPs. The activity of ArfGAPs is dependent on the presence of phosphoinositides and is implicated in cellular processes such as membrane trafficking and remodeling of the actin cytoskeleton. ASAP3 has been found to be up-regulated in 80% of the hepatocellular carcinomas examined. Initial biochemical characterization reveals that ASAP3 shows class-specific GAP activity on Arf proteins, preferring Arf5 over Arf1 and Arf6. ASAP3 antibody has beed developed through the NCI antibody collaboration program and is ideal for Cancer and Signal Transduction research.Target Information: This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]. |
| Immunogen | This antibody was prepared from whole rabbit serum produced by repeated immunizations with recombinant human UPLC1/ASAP3 protein. Immunogentype:Recombinant |
| Other Names | ACAP4|CENTB6|DDEFL1|UPLC1|ARF6 GTPase-activating protein|ArfGAP with SH3 domain|ankyrin repeat and PH domain 3 1|arf-GAP with SH3 domain|ANK repeat and PH domain-containing protein 3|centaurin|beta 6|development and differentiation enhancing factor-like 1|development and differentiation-enhancing factor-like 1|protein up-regulated in liver cancer 1|up-regulated in liver cancer 1 (UPLC1)|ArfGAP with SH3 domain, ankyrin repeat and PH domain 3|ASAP3|9430088F20Rik|Gm140|zgc:113885|ankyrin repeat and PH domain 3 |
| Gene, Accession # | Gene ID: 55616 |
| Catalog # | ABIN233800 |
| Price | $537 |
| Order / More Info | ASAP3 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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