MCM4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | MCM4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Immunofluorescence, Immunohistochemistry, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DNA replication licensing factor MCM4 (MCM4), also named Cdc21, acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of MCM4 protein. Target Information: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse MCM4 |
| Other Names | cdc21|CDC21 homolog-B|DNA replication licensing factor mcm4-B|P1-CDC21-B|minichromosome maintenance protein 4-B|xMCM4-B|minichromosome maintenance complex component 4 L homeolog|mcm4.L|Minichromosome Maintenance Deficient 4|MCM4|CDC54|NKCD|NKGCD|P1-CDC21|hCdc21|CDC21 homolog|DNA replication licensing factor MCM4|homolog of S. pombe cell devision cycle 21|minichromosome maintenance complex component 4|MCM4 minichromosome maintenance deficient 4|minichromosome maintenance protein 4|19G|AI325074|AU045576|Mcmd4|mKIAA4003|mcdc21|mini chromosome maintenance deficient 4 homolog|minichromosome maintenance deficient 4 homolog|cb1025|fc12c09|fj85g09|hm:zeh1616|wu:fc12c09|wu:fj85g09|zeh1616 |
| Gene, Accession # | Gene ID: 17217, 29728 |
| Catalog # | ABIN7074631 |
| Price | $286 |
| Order / More Info | MCM4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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