PVRL2 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | PVRL2 |
| Clone | 502-57 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunoassay, Immunohistochemistry (Frozen Sections), Immunoprecipitation, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice. Monoclonal antibody 502-57 has been raised against the extracellular domain of mouse nectin-2. The antibody cross reacts with human nectin-2. Target Information: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | CD112|HVEB|PRR2|PVRR2|herpesvirus entry protein B|nectin-2|poliovirus receptor-like 2|poliovirus receptor-related protein 2|nectin cell adhesion molecule 2|NECTIN2|Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B)|PVRL2|AI325026|AI987993|MPH|Pvr|Pvs|herpes virus entry mediator B|herpesvirus entry mediator B|mHveB|murine herpes virus entry protein B|murine herpesvirus entry protein B|poliovirus receptor homolog|poliovirus sensitivity|poliovirus receptor related 2 |
| Gene, Accession # | Gene ID: 19294 |
| Catalog # | ABIN2191800 |
| Price | $830 |
| Order / More Info | PVRL2 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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