GPX4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | GPX4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.15 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Glutathione Peroxidase 4 (GPx4, also known as PHGPx) functions as an antioxidant and also plays a role in redox regulation, sexual maturation, inflammation, apoptosis, and differentiation. GPx4 was found to have an important role in preventing lipid peroxidation, and has been discussed primarily as the glutathione peroxidase protecting biomembranes against oxidative stress. GPx4 can react with free hydrogen peroxide as well as with a wide range of lipid hydroperoxides, including those derived from cholesterol and cholesteryl esters. GPx4 is the only GPx to use phospholipid hydroperoxides as substrates. It can also reduce thymine hydroperoxide. In contrast to GPx1 and GPx3, GPx4 can use a wide range of reducing substrates in addition to glutathione. GPx4 is expressed in high levels in testes, suggesting a role in male fertility. It has also been identified as an enzymatically inactive structural protein of the mitochondrial capsule of sperm.Target Information: May constitute a glutathione peroxidase-like protective system against oxidative stresses (By similarity). |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the of mouse GPx4 protein. |
| Other Names | GPx-4|GSHPx-4|MCSP|PHGPx|snGPx|snPHGPx|phospholipid hydroperoxidase|phospholipid hydroperoxide glutathione peroxidase|mitochondrial|sperm nucleus glutathione peroxidase|glutathione peroxidase 4|GPX4|nuclear|cb563|cb691|PHGPxa|sb:cb563|zgc:92253|wu:fb82e03|glutathione peroxidase 4a|gpx4a|1700027O09Rik|mtPHGPx|sperm nuclei glutathione peroxidase|ATGPX4|F11L15.5|glutathione peroxidase 4 (phospholipid hydroperoxidase)|GP-GPx4|phospholipid-hydroperoxide glutathione peroxidase|phospholipid hydroperoxide glutathione peroxidase 4|gpx4-a|gpx4-b|gpx4b|glutathione peroxidase 4 S homeolog|glutathione peroxidase 4 b (phospholipid hydroperoxidase)|gpx4.S |
| Gene, Accession # | Gene ID: 2879, 625249 |
| Catalog # | ABIN129715 |
| Price | $537 |
| Order / More Info | GPX4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155
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