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Antigenic Specificity | ATF-2 |
Clone | W21106A |
Host Species | Rat |
Reactive Species | human, mouse |
Isotype | IgG2b, κ |
Format | purified |
Size | 25 µg |
Concentration | n/a |
Applications | Western Blot (WB), ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-ATF-2. The Activating Transcription Factor 2 (ATF-2), also known as CREB2 and CREBP1, contains a Basic Leucine Zipper (bZIP) domain and a C2H2-type zinc finger domain. ATF-2 binds to both DNA response factors AP-1 and CRE and belongs to the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cytosolic tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. ATF-2 activity can be initiated by various forms of cellular stress. Several studies have shown aberrant ATF-2 activation in the development and progression of mammalian skin tumors. ATF-2 may mediate carcinogenesis induced by the mutant Ras protein and regulate the maintenance of the invasive cancer phenotype of several epithelial cell types. ATF-2 has also been shown to be phosphorylated at its C-terminus (serine 472 and 480 in mice, serine 490 and 498 in human) by ATM during double-strand breaks. Mice with mutations of these two serines are sensitive to irradiation and more prone to tumorigenesis under p53 knockout condition. |
Immunogen | Partial Recombinant human ATF2 protein |
Other Names | activating transcription factor 2 formerly; ATF2; cAMP-responsive element-binding protein 2; CREB2; CREBP1; CRE-BP1; cyclic AMP-dependent transcription factor ATF-2; HB16; MGC111558; TREB7 |
Gene, Accession # | Gene ID: 1386 |
Catalog # | 630051 |
Price | $205 |
Order / More Info | ATF-2 Antibody from BIOLEGEND |
Product Specific References | n/a |