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Antigenic Specificity | Jun Phospho (Ser73) |
Clone | A19012A/R/C |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG1, κ |
Format | Alexa Fluor® 647 conjugate |
Size | 25 tests |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alexa Fluor® 647 anti-Jun Phospho (Ser73). c-Jun is the first oncogenic transcription factor ever discovered. It heterodimerizes with members of the Fos protein family, such as c-Fos, to form the AP-1 transcription factor complex, exhibiting both activating and repressive functions depending on the interacting partner and promoter sequence context. c-Jun is required for cell cycle progression, and is protective against DNA damage, such as that resulting from ultraviolet light exposure. c-Jun is also overexpressed in many cancers including lung, breast and vulvar cancer, and is a target for anti-cancer therapies. Phosphorylation of c-Jun at serine 63 and 73 is activational, and mediated by the MAPK signaling cascade. |
Immunogen | Synthetic peptide of human c-Jun phosphorylated at Ser73 |
Other Names | Transcription factor Jun, activator protein 1 (AP1), Proto-oncogene c-Jun, transcription factor AP-1 subunit Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39 |
Gene, Accession # | Gene ID: 3725 |
Catalog # | 605555 |
Price | $160 |
Order / More Info | Jun Phospho (Ser73) Antibody from BIOLEGEND |
Product Specific References | n/a |