Description | APC anti-T-bet. T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and |
Product Specific References | PubMed: 24443555, 27069112, 27653690, 27802341, 29352742, 29752063, 29625895, 29358051, 30314757, 30392830, 30894532, 30540940, 30566882, 31603425, 30314757, 29625895, 29752063, 29358051, 30635238, 30540940, 30392830, 30566882, 30314757, 31775026, 32101732, 34125490, 32860752, 34081922, 34216539 |