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Antigenic Specificity | Human CD28 |
Clone | QA17A12 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1, κ |
Format | purified, azide-free, low-endotoxin |
Size | 1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC), Costim |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ultra-LEAF™ Purified anti-human CD28 Recombinant. CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. |
Immunogen | n/a |
Other Names | T44, Tp44 |
Gene, Accession # | Gene ID: 940 |
Catalog # | 377204 |
Price | $149 |
Order / More Info | Human CD28 Antibody from BIOLEGEND |
Product Specific References | n/a |